What is .APPLICATION file extension?
File created for ClickOnce, a Microsoft framework used to deploy Windows applications over the Web; stores program deployment properties in an XML format, including name, version, description, deployment options, and dependencies; may also contain a digital signature.
APPLICATION files were designed to provide easy "one click" deployments of user-level Windows applications. They have a corresponding .APPREF-MS file that activates ClickOne for a program, which subsequently executes within the .NET framework in Windows.
You can see a list of software programs here on www.easyfileopener.org that can open this file type so that you don’t need to search for it on the web. You can then open your file with this extension using a software listed below.